The affinity, cAMP activity, and insulinotropic activity in vitro all decline when Ala 8 is substituted with Gly 8 (IC 50 : 44.9 nM220 nM;EC 50 : 0.15 nM1.11 nM).19 Substitution with Aib 8 hardly influences the cAMP activity and substitution with D-Ala 8 induces little or no change in the affinity or cAMP activity.11 Considering GIP analogues, Gly 2 GIP shows improved cAMP activity and insulinotropic activity in vitro,20 while the cAMP activity of D-Ala 2 GIP matches that of GIP.21 The introduction of Aib 2 into GIP has also been reported, and it seems that it does not obviously affect the cAMP activity.15,22 Comprehensively, using Aib 2 is likely to only minimally influence the GLP-1 and GIP activities
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