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In this case, the diminished affinities of the D-Ala analogues relative to the natural agonists could be compensated by an increase in average number of G proteins activated to cause the observed similarity in receptor activation efficacies of the D-Ala analogues relative to GLP-1 and exendin-4

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In some embodiments, the otic pharmaceutical formulation comprises about 84% by weight of the triglycerides

Most cases can be managed successfully without discontinuing therapy