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Mov Disord 25(11):16701674 Sohouli MH, Razmpoosh E, Zarrati M, Jaberzadeh S (2022) The effect of omega-3 fatty acid supplementation on seizure frequency in individuals with epilepsy: a systematic review and meta-analysis

doi: 10.1016/j.bbadis.2025.167752 89 HuckO.MulhallH.RubinG.KizelnikZ.IyerR.PerpichJ

Phosphorylation of OPTN by TANK-binding kinase 1 (TBK1) enhances its capacity to bind to poly-Ub chains, thus creating a positive feedback cycle that promotes mitophagy [66, 67]

and the metabolism of carbohydrates

Many patients end up using both, which is perfectly reasonable because the mechanisms barely overlap