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For those with persistent closed comedones, consulting a dermatologist may provide access to more advanced treatments, such as chemical peels or microdermabrasion, which can further help in managing and preventing their recurrence

Individual tolerance varies significantly, and dose timing matters considerably when managing cumulative digestive effects

Their long-lasting effects in the body mean they would still overlap, posing the same risks as taking them on the same day

Such studies could incorporate standardized definitions for renal outcomes, such as the composite of 40% GFR decline, ESKD, or renal death, as primary endpoints, which would improve comparability

People with severe gastrointestinal conditions may tolerate these medications poorly