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The approval of GLP-1 RAs, starting with exenatide in 2005, followed by semaglutide and oral formulations, has expanded treatment options for patients seeking effective, long-term solutions for T2DM and obesity (15)

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Eli Lilly $LLY stock rose 4.4% in premarket trading on Monday after full Phase 3 trial results for its experimental weight loss drug retatrutide showed participants on the highest dose losing an average of 28.3% of their body weight over 80 weeks.

Fifthly, the self-renewal of NCs occurs infrequently and is not unlimited, aspects that oppose the stem/progenitor cell function [58]