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(3) Achieving therapeutic concentrations in relevant tissues, such as the brain or endothelium, without inducing systemic toxicity remains a significant hurdle

Neuroprotection: Protects against ischemic stroke and CNS damage via the gutbrain axis (PMC8504390)

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Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants

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