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Quick Answer: Semaglutide has not been established as a cause of colitis in FDA labeling or major clinical trials, though isolated post-marketing reports exist

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doi: 10.1016/j.peptides.2005.02.016

In the case of KATO-III cells, antiproliferative effects were shown at concentrations above 100 g/mL, while in LS174 cells, cytotoxic properties of bromelain were evidenced above 30 g/mL and its cytotoxicity increased with higher bromelain concentrations at 72h (81)