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miR-144 is the first miRNA identified as an Nrf2 negative regulator (Sangokoya et al., 2010), and miR-144 can also promote autophagy (Chen et al., 2015)

Treatment with the non-essential metals resulted in both enrichment and depletion of cells lacking membrane transporters, as suggested by the enrichment or depletion of the respective sgRNAs, implying that some transporters were increasing, and others decreasing, the toxicity of the three metals (Fig 2BD, Table 1)