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10.1016/j.cbpc.2021.109141 31 Di PierroD.CiaccioC.SbardellaD.TundoG
Im amazed at how much energy I have and Ive lost 4lbs my first week
Mechanism and Side Effects of IGF-1 LR3 Aug 12022 IGF-1 LR3 is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1).The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability
The peptide downregulates or inhibits key lipogenic enzymes including fatty acid synthase and acetyl-CoA carboxylase, which are responsible for converting excess dietary carbohydrates and other substrates into fatty acids for storage
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