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This is why, for example, short-acting benzodiazepines such as alprazolam and lorazepam are more difficult to discontinue than long-acting benzodiazepines such as diazepam and clonazepam

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The phagophore, and hence autophagosome formation requires the generation of an initiation complex named Unc51-like kinase 1 (ULK1) complex composed of ULK1, Atg13, FIP200, and Atg101 (Yang et al., 2015