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Inform patients of the potential risk for worsening renal function and explain the associated signs and symptoms of renal impairment, as well as the possibility of dialysis as a medical intervention if renal failure occurs

Intestinal and hepatic biochemical analysis (iFABP, AST, ALT) Plasma levels of aspartate aminotransferase (Abcam, Cambridge, MA) and alanine aminotransferase (Cloud-Clone, Katy, TX) were determined with commercial kits

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A 2021 study published in the New England Journal of Medicine showed semaglutide could resolve non-alcoholic steatohepatitis (NASH), though evidence for consistent fibrosis improvement remains inconclusive

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