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this results in reduced transcription of mitochondrial ribosomal proteins and mitochondrial transcription factors, and subsequently halting protein translation 101,102

Mice lacking the modifier subunit of GCL, have a 60% reduction in glutathione, accompanied by abnormal cortical gamma synchrony, decreased parvalbumin interneurons (PV-IN) and behavioral phenotypes relevant to schizophrenia.(49-51)

After addition of 10 l Premix WST-1 solution to each well, cells were incubated at 37C for another 1 hour and the absorbance was determined at 440 nm using a microplate reader

Shimozaki K, Sukawa Y, and Beppu N, et al (2020) Multiple immune-related adverse events and anti-tumor efficacy: real-world data on various solid tumors Cancer Manag Res 12 45854593 PMID: 32606951 PMCID: 7305832 56

This compound is not intended for diagnostic or therapeutic use in humans or animals