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GLP-1RAs, including exenatide, albiglutide, dulaglutide, and lixisenatide, demonstrated remarkable efficacy in improving glycemic control by lowering postprandial glucose levels and HbA1c

GLP-1 signaling acts, at least in part, through transcriptional targets lst-1 and sygl-1 to repress the GLD-1, GLD-2 and SCF PROM-1 meiotic entry pathways (reviewed in [4])

Diabetes is characterized by hyperglycemia, oxidative stress and abnormalities in lipid metabolism

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The most common side effects reported with GLP-1 receptor agonists include nausea, vomiting, constipation, and mild digestive discomfort, particularly during the dose escalation phase