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The similarity in their TMD interaction patterns is consistent with the strong correlation in the impact of TMD mutagenesis for these two agonists (Fig
It does not predict response to any specific compound or program
Availability of data and materials No datasets were generated or analysed during the current study
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Of note, over the last years, an array of unimolecular GLP1-based poly-agonists, with different mechanisms of action, have been developed and experimentally validated for the treatment of metabolic syndrome, holding superior efficacy relative to conventional GLP1-RA 33,34,35
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