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Interestingly, a post-hoc analysis of the Prediabetes Lifestyle Intervention Study (PLIS) suggested that patients achieving prediabetes remission differed from non-responders in improvement in whole body insulin sensitivity, visceral adipose tissue (VAT) and intrahepatic fat rather than insulin secretion upon a similar weight loss 76

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Furthermore, the 5xFAD mouse, which overexpresses human APP with three mutations along with human presenilin 1 (PS1) harboring two mutations, begins to show significant apathy-like behaviors from six months of age, as measured by nest-building, burrowing, and marble burying (Pugh et al., 2007