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It has been reported that decreased level of hexokinase (HK) in streptozotocin (STZ)-induced diabetic rodents inhibits glucose conversion into glucose-6-phosphate leading to hyperglycemia [24]

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The worsening of symptoms after stopping glutathione reflects the return of the underlying condition elevated oxidative stress from chronic disease, mitochondrial dysfunction, or metabolic pathology that glutathione was temporarily mitigating