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[14] GLP-1 agonists already cause nausea, vomiting, and gastroparesis-like symptoms in a meaningful proportion of patients

Glycine: This amino acid is included for its potential to stimulate GLP-1 release through glycine-gated chloride channel activation. This mechanism involves activating chloride channels in intestinal cells, leading to a series of events that trigger GLP-1 release

Emerging research suggests cinnamon may increase GLP-1 as part of its broader blood sugar benefits, but more studies are needed to confirm its effects

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In part, the paucity of evidence on this topic is related to the lack of rich clinical data on a broad range of patients with enough long-term data following use of these medications for indications such as obesity