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The textbooks specifically describe it as having no malignant potential, with only a single case ever reported of apparent malignant transformation

g i ) Representative whole dorsal striatal images of NPY immunofluorescence from Trkb Penk-WT control ( g ), Trkb Penk-KO mutant injected at 3 M with Gsto2 -shRNA ( h ) or scrambled-shRNA in the striatum ( i ) and analysed at 15 W

Received: 11 Jun 2025 | Revised: 29 Jul 2025 | Accepted: 31 Jul 2025 | Published: 27 Jan 2026 1

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Insulin has roles in synaptic plasticity, modulating tau phosphorylation, amyloid metabolism, and reducing oxidative stress