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Toxicology Nonhuman After oral administration of a methanolic kratom extract to rats (1001000 mg/kg) for 14 days, mild nephrotoxicity and moderate to severe hepatotoxicity were observed, with elevations in alanine aminotransferase, aspartate aminotransferase, albumin, triglycerides, and cholesterol (Harizal et al., 2010)

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