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TB-500 introduction appears to influence cytokine production and accelerate wound healing in models of corneal wounds

103 In one randomized clinical trial in 70 volunteers with chronic tinnitus, both 3 mg of melatonin daily and a standard dose of sertraline (Zoloft) (an antidepressant medication) for three months reduced tinnitus severity, but melatonin was more effective

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The absence of effects in the limited human data does not confirm long-term safety

Research suggests it has a relatively mild safety profile, but long-term safety studies are still limited