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Without DAC (Mod GRF 1-29), the half-life is around 30 minutes, requiring more frequent dosing but preserving the natural pulsatile GH release pattern

This cycling approach prevents receptor desensitization and gives the body time to consolidate the changes produced during the active phase

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This study analysed a group of Dutch Caucasians with a polymorphism in the promoter of the IGF-1 gene [129, 218]

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