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GLP-1 acts on the brains appetite regulation centers to reduce hunger and increase satiety, slows the rate at which the stomach empties (promoting a longer-lasting feeling of fullness), and improves insulin sensitivityreducing blood sugar spikes and supporting healthier metabolic function overall

Sulfonylureas (such as glipizide, glyburide, and glimepiride) also increase hypoglycemia risk when combined with semaglutide

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The Shared Foundation: Incretin Biology Both Ligands Exploit Before cataloguing differences, it is worth being explicit about the common biology, because the differences only make sense against that shared backdrop