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Growth Factor Pathway Modulation Beyond VEGF, BPC-157 has been documented to influence the expression or activity of several growth factors and signaling intermediates relevant to tissue organization: EGF receptor (EGFR): BPC-157 has been shown to upregulate EGFR-dependent signaling in gastrointestinal epithelial models, consistent with its gastroprotective effects (Sikiric et al., 2016, Current Neuropharmacology

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Khan SR, Byer KJ, Thamilselvan S, Hackett RL, McCormack WT, Benson NA et al (1999) Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells

In the past 2 years, two novel pathways unrelated to GPX4 have been discovered to inhibit lipid peroxidation associated with ferroptosis