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MC4R are commonly present in the central nervous system

Glucagon-like peptide-1 receptor agonist (GLP-1RA) and sodium-glucose cotransporter 2 inhibitor (SGLT2i) are currently recommended as first-line hypoglycaemic agents for patients with diabetes with established cardiovascular disease or multiple cardiovascular and renal risks [10]

Proper dosing requires slow titration to maximum tolerated doses, typically semaglutide 2.4mg weekly plus cagrilintide 2.4mg weekly, though conservative approaches using lower maintenance doses work well for many

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