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Glutaminase inhibitors, such as CB-839, have shown promise in preclinical studies and early-phase clinical trials, demonstrating their ability to impede glutamine catabolism and disrupt the supply of glutamate, a precursor for numerous biosynthetic pathways critical for cancer cell survival and proliferation [12,55]

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1 As we noted in Part 1 of this 3-part series, 2 clozapine remains the most efficacious, but most tedious, antipsychotic available to psychiatrists because of its monitoring requirements and potential side effects

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