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3 The mechanisms of GLP-1 with dual or triple receptor agonists in MASLD treatment 3.1 The mechanisms of GLP-1 receptor agonists in MASLD treatment 3.1.1 Regulation of hepatic lipid metabolism GLP-1RAs exert multifaceted regulatory effects on hepatic lipid metabolism, which are pivotal to their therapeutic potential in MASLD

In particular, the mitochondrial inner membrane is impermeable to fatty acyl-CoA thioesters and, thus, the specialized CS, for transporting fatty acids across mitochondrial membranes has evolved 18