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Butyrate acts as a HDAC inhibitor in immune cells, suppressing the expression of pro-inflammatory cytokines (TNF-, IL-6) and enhancing the integrity of epithelial tight junctions

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OLs show faster differentiation yet slower remyelination in white matter vs gray matter in mouse models and MS lesions, and reduced remyelination in spinal cord vs deep white matter 75,76,77,78,79,80

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