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doi: 10.1194/jlr.M045971 57 OrlandoUCookeMCornejo MacielFPapadopoulosVPodestEJMalobertiP

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By enhancing deep sleep stages and improving sleep efficiency, DSIP facilitates neuroendocrine processes that occur during sleep including hormonal balance, tissue repair, and stress regulation all key components of recovery

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Thus, mTORC1 promotes the nuclear translocation of the cAMP response element-binding protein (CREB) which stimulates the transcription of the anti-apoptotic gene MCL-1 in the nucleus and the upregulation of the Bcl-2 family protein myeloid cell leukemia 1 (Mcl-1) [300]