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IGF axis activity associates with deregulated immune genes and immune infiltrating cells in PCa tissues To test the clinical relevance of these findings we interrogated public RNA-seq data from the Prostate Adenocarcinoma Firehose Legacy dataset in cbioportal (www.cbioportal.org/study/summary?id=prad_tcga) 30

The primary functions of IDH1 and IDH2 are to serve as producers of NADPH to enhance the cellular responses to oxidative stress and the generation of reactive oxygen species, ROS

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