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Weight Loss and Initial Fluid Changes Tirzepatide produces substantial weight lossclinical trials show average reductions of approximately 15% of body weight over 72 weeks in obesity trials (SURMOUNT-1) and somewhat less in type 2 diabetes trials (SURPASS program)

Many who take this class of drug, known as glucagon-like peptide 1 agonists (GLP-1), feel the pros outweigh the cons

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