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Citrulline malate increases NO production and decreases muscle soreness

It promotes angiogenesis, accelerates wound healing, reduces inflammation, and appears to protect against various forms of GI damage including those caused by NSAIDs, a class of drugs frequently used by lupus patients for joint pain and inflammation

Once absorbed, it helps neutralize free radicals, support liver detox enzymes, and maintain healthy antioxidant balance

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Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes