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Consequently, therapeutic strategies that simultaneously enhance neurotrophic signaling and restore neurogenesis may offer superior and more durable antidepressant effects compared with monoaminergic modulation alone (44, 45)

The presence of these transporters enables the uptake of glucose from the blood providing an energy source to the cells and restoring normal glucose levels

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Abnormal renal retention of sodium leads to concomitant water retention, expansion of plasma volume, and subsequently edema and ascites