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Oocytes containing both female and male pronuclei (regardless of the stage of decondensation) relative to the total number of oocytes that matured were considered fertilized and were classified as normal (2PN) according to the numbers of swollen sperm heads and pronuclei in the cytoplasm

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This creates a devastating feedback loop: the lack of glutathione allows oxidative stress to run rampant, which further impairs the methylation cycle, which in turn prevents the production of more glutathione

In a prospective observational study of pregnant women, delayed treatment with acetylcysteine was associated with increased risk of miscarriage and fetal death

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