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Key safety measures include: Dose optimization: Initiating therapy at the lowest effective doses Blood-pressure monitoring: Regular assessment due to additive vascular effects Prescribed administration: Strict adherence to clinician-directed timing and dosing Potential Side Effects of Combination Therapy Combination therapy may result in additive side effects from both medications, including nausea, flushing, headache, gastrointestinal discomfort, and blood-pressure changes
It also stimulates cell adhesion and is associated with inflammation, cellular senescence, tissue aging and obesity
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doi: 10.1186/S12906-017-1984-9 182 LeeJKKimSYKimYSLeeWHHwangDHLeeJY
