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It may prove useful in some individuals but it remains an extrapolated and nuanced position, not yet one settled with robust evidence

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Furthermore, these results are consistent with previous 1 H-MRS studies in humans that found IV ketamine elevates ACC glutamine and Glx immediately 9,10 and ACC glutamate levels after 35 min in healthy individuals 8 , together with studies in patients with MDD that reported an acute mPFC Glx increase 11 and an increase prefrontal 13 C-glutamine 13 following IV ketamine administration

These effects create a powerful metabolic shift toward fat utilization and energy expenditure