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Insulin directly stimulates tumor-associated fibroblasts (TAF) through activating the IRS-PI3K-AKT-mTOR signaling pathway and inactivating the FoxO1 signal pathway (Yang et al., 2016

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It should be noted that although NSDR may support relaxation and recovery, it still does not fully replicate the restorative effects of sleep, which are critically important for multiple biological processes, and for healthy aging in general