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10.1186/s13643-016-0384-4 [DOI] [PMC free article] [PubMed] [Google Scholar] Parry-Strong A., Langdana F., Haeusler S., Weatherall M., Krebs J

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This patient with documented PD-L1 expression was treated with the checkpoint inhibitors pembrolizumab, ipilimumab, and nivolumab with pain improvement, but no objective response in disease progression

Methods: We use mathematical models for hepatic glutathione metabolism, including one-carbon metabolism and acetaminophen detoxification, to investigate how the activation of certain enzymes by estradiol leads to dramatic changes in reaction velocities and metabolite concentrations

10.1562/0031-8655(2002)0750346PAPOAE2.0.CO2 197 VicentiniJ