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This HexaPro antigen was used in a regimen termed prime and spike, in which a priming dose was administered intramuscularly to induce peripheral immune memory and a boosting dose was administered intranasally to expand and recruit spike-specific T and B cells to the mucosa [167]

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The majority of the studies (see above in red) are preclinical studies in rodents, the vast majority of which have been done by a single research group in Croatia, which has been rinsing and repeating the same approach for decades