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Each targets a different receptor pathway and can enhance GH release or recovery, but over-stacking increases the risk of elevated cortisol, water retention, or insulin sensitivity changes

Gla residues are usually involved in binding calcium, and are essential for the biological activity of all known Gla proteins

Experimentally, other stress paradigms such as hemorrhage, oxidative stress, intraperitoneal hypertonic saline, restraint/immobilization, foot shock, forced swimming, or shaking are used to study the stress responses in animals

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70 Additionally, lactylation at K91 of transcription factor EB (TFEB) impedes it from interacting with E3 ubiquitin ligase WW domain-containing E3 ubiquitin protein ligase 2 (WWP2), thereby inhibiting TFEB ubiquitination and proteasome degradation and eventually augmenting TFEB activity