glp-1 review article A in Nature Reviews Endocrinology discusses why patients discontinue receptor agonists and tirzepatide, the metabolic and cardiovascular effects of this discontinuation, and the need for additional research on how to Frontiers | Exploring the multifaceted

Antioxidants and statins (3-hydroxy-3-methylglutary-coenzyme A reductase inhibitors) A three-year randomized controlled trial in 160 patients with coronary heart disease (CHD) and low high-density-lipoprotein (HDL) levels found that a combination of simvastatin (Zocor) and niacin increased the HDL2 subfraction level (considered the most cardioprotective), inhibited the progression of coronary artery stenosis (narrowing), and decreased the frequency of cardiovascular events, such as myocardial infarction and stroke (130)

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TMAO can inhibit the activation of FXR by changing the size of the bile acid pool, which may weaken or inhibit the beneficial effect of FXR, affect the glucose metabolism of the host, and promote the occurrence and development of insulin resistance and NAFLD

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