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Under NICE Technology Appraisal 875, Wegovy is recommended for use within specialist weight management services for a maximum of 2 years on the NHS

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While not a formal contraindication, clinicians generally defer initiation of tirzepatide until patients with hyperthyroidism are euthyroid, as overlapping symptoms and cardiovascular effects could complicate assessment of medication tolerance and efficacy

Semaglutide has been studied for weight management, type 2 diabetes, and cardiovascular risk reduction in certain patients

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