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Free radical metabolite of uric acid

Diabetes Care 30 (3), 719721

Darwish MA, AboYoussef AM, Khalaf MM, AboSaif AA, Saleh IG, Abdelghany TM (2017) Vitamin E mitigates cisplatininduced nephrotoxicity due to reversal of oxidative/nitrosative stress, suppression of inflammation and reduction of total renal platinum accumulation

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Many authors discuss the inadequacy of guidelines when written based on general consensus and expert opinion, rather than on high-level clinical evidence, noting that case reports, retro/prospective studies, and observational studies, as is mostly what is currently available, are often insufficient to inform clinical practice (Australian Diabetes Society, National Association of Clinical Obesity Services, Gastroenterological Society of Australia, and Australian and New Zealand College of Anaesthetists n.d.)