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Intestinal Anti-Inflammatory Activity (KPV): KPV (Lys-Pro-Val) is a tripeptide that research suggests can attenuate NF-kB signaling in intestinal epithelial cells, reducing pro-inflammatory cytokine expression relevant to colitis models
Therapeutic strategies targeting this axis (Figure 2), such as BH4 supplementation, NOX inhibitors, and lifestyle modifications (e.g., exercise, Mediterranean diet), aim to restore redox balance and endothelial function, though their efficacy varies by HTN stage and comorbidities
Improved physical and mental performance : By optimizing detoxification and reducing oxidative stress, glutathione also improves physical and mental performance
Materials and methods: Glucose tolerance (oral glucose tolerance test), metabolic flexibility (RQ) & insulin sensitivity (euglycemic hyperinsulinemic clamp/EHC & indirect calorimetry), resting energy expenditure & metabolic substrate preference (indirect calorimetry), body composition (bioelectrical impedance), physical fitness (Rockport 1 mile walk test, VO 2 max
