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One of those dual agonists, tirzepatide (Mounjaro/Zepbound, Eli Lilly), was associated with a mean 14.7% weight loss for adults with overweight or obesity and type 2 diabetes in the SURMOUNT-2 trial compared with a 3.2% weight loss with placebo

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Additionally, electron micrographs of ER-IP samples showed that the bead-bounded fraction contains intact ER ministacks with ribosomes on the surface, verifying the specificity of the approach (Fig