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Groundbreaking studies by Krauss and co-workers (461) described two major patterns for LDL subpopulations based on size and density of the LDL particles

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Tail vein blood (~5-10 l) was collected serially at 0, 30, 60, 90 and 120 min post-challenge through the tail-nick method (19) The blood collection procedure was approved by the Institutional Animal Care and Use Committee of City of Hope in accordance with the NIH Guidelines for Survival Blood Collection in Mice and Rats ( Blood glucose concentration was measured with an Accu-Chek Compact Plus glucometer (Roche Diagnostics Ltd.)

(PubMed) Wise RA, Holbrook JT, Criner G, et al

Another important benefit is appetite control