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doi: 10.3389/frdem.2026.1745504 Received 13 November 2025 Revised 21 December 2025 Accepted 16 January 2026 Published 04 February 2026 Volume 5 - 2026 Edited by Matea Nikolac Perkovi, Rudjer Boskovic Institute, Croatia Reviewed by Xifeng Wang, First Affiliated Hospital of Nanchang University, China Paolo Abondio, IRCCS Institute of Neurological Sciences of Bologna (ISNB), Italy Updates Copyright 2026 Perezcano and Prez-Coria

Cachexia, Sarcopenia Muscle 11 (5), 13061320

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10.1093/jn/134.3.489 12

We systematically examine key approaches, such as targeting neuroinflammatory cascades, modulating neurotrophic factors, and mitigating glutamate-mediated excitotoxicity