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We summarize key mechanisms of action, categorize clinically relevant peptide classes, and address current limitations, including gaps in human data, safety considerations, and regulatory ambiguity

Elevated intracellular levels of ferrous iron (Fe 2+ ) or lipoxygenase (LOX) activity promote lipid peroxidation, and an imbalanced antioxidant system prevents the timely clearance of excessive L-OOHs

A history of active cancer is a major contraindication for these therapies, as growth-stimulating hormones could theoretically influence tumor growth

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The biologic potential of various categories of melanocytomas needs to be determined by careful clinical observational studies in order to guide optimal patient management