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Sacubitril/valsartan attenuates myocardial inflammation, hypertrophy, and fibrosis in rats with heart failure with preserved ejection fraction

2 Activates Cellular Regeneration Stimulates fibroblast migration and collagen synthesis to rebuild damaged muscles, tendons, and joints

This altered microenvironment enhances production of matrix-degrading enzymes (e.g., MMPs, ADAMTS), which degrade cartilage matrix and disrupt joint homeostasis (Sanchez-Lopez et al., 2022

1 Narcolepsy is a chronic hypothalamic neurodegenerative disorder and a quite disabling condition, presenting with several sleep-wake cycle related symptoms, such as excessive sleepiness (ES) and dissociative manifestations of REM sleep, such as cataplexy, sleep paralysis, hypnagogic hallucinations, and early REM sleep (REM sleep naps, SOREMP) 2