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Serious symptoms are uncommon but need medical attention, including significant swelling, chest pain, shortness of breath, sudden vision changes, allergic reaction symptoms, or major mood changes

Understanding your genetic predisposition helps your provider optimize both your dose and schedule for maximum efficacy and minimal side effects

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Compared with other CVOTs involving GLP-1RA, participants in the AMPLITUDE-O trial had the longest duration of diabetes (15 years), lowest mean eGFR (72 ml/min/1.73 m 2 ) with a higher percentage (32%) of people with renal disease (eGFR 2560 mL/min), highest glycosilated hemoglobin (8.9%), and highest percentage of insulin use (62%) or sodiumglucose transporter-2 inhibitors (SGLT-2i) (15%) at baseline, thus identifying a more fragile population