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It has also been argued that the inhibition of mitochondrial complex 1 is an important contributor to the cytotoxic effects of metformin and has been observed in cancer cells and supported by data showing reduced inhibition of tumor growth in cancer cells expressing a metformin-resistant yeast complex 1, NDI1 (136, 243)

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However, the OXPHOS-PPP based prognostic risk predictive model performed better than the 47 metabolic gene-based model (Supplementary Fig

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